Government matches Malaghan Institute’s ambitions for cancer immunotherapy

The Malaghan Institute’s ambitious plans to establish a platform for CAR T-cell cancer therapy has received the backing from the New Zealand government in a funding deal announced recently.

The Ministry of Business, Innovation and Employment’s Partnership Scheme will contribute up to 40% of the estimated cost – to help establish CAR T-cell manufacturing in New Zealand and develop new CAR T-cell therapies for clinical use.

The Malaghan Institute previously announced its partnership with the Hunan Zhaotai Medical Group in China to develop and trial a new third-generation CAR T-cell therapy in New Zealand. This treatment has the potential to offer benefits over existing second- generation CAR T-cells currently licensed in the US, Europe and Australia. The organisations have formed a joint venture – Wellington Zhaotai Therapies Limited – retaining international rights for the construct outside China.

Malaghan Institute General Manager Mike Zablocki says the co-funding is a clear signal from the government that it sees a big future for human immune therapy – for both the health and wealth of New Zealand.

“This is a growing, high tech, knowledge-intensive sector. This partnership funding will help transform our existing plans for a single phase I trial – already well underway – into a highly focused program of expanding economic opportunity for New Zealand.

“We expect clinical trials to enable early access to CAR T-cell therapy for New Zealanders, and to establish the local manufacturing capability and regulatory processes needed for these personalised treatments. We hope this will reduce the barriers to entry for similar therapies and ultimately improve access to effective new cancer treatments for all New Zealanders.”

Mr Zablocki says support from the community, including through the Freemasons CAR T-cell Research Programme, the Lion Foundation, the Thompson Family Foundation, Keith and Faith Taylor and David Downs’ Down with Cancer programme has been, and will continue to be, critical to the success of its CAR T-cell programme and the Institute’s ability to explore new frontiers.

“The trials aim to demonstrate the competitive advantage of our therapy with a view to securing an industry deal to capitalise further research and development in New Zealand and get this type of treatment into New Zealand hospitals.”

Director of the Malaghan Institute Professor Graham Le Gros says the funding is a vote of confidence in New Zealand scientists and researchers, and the capability the Malaghan Institute has built over the years thanks to its many supporters.

“Government has understood the potential of immunotherapy for a long time, and that has helped secure this partnership funding.

For more information on the Institute’s CAR T-cell programme, visit

www.malaghan.org.nz/what-we-do/car-t-cell/

A revolutionary new approach to fighting cancer, the Malaghan Institute is working in partnership with Wellington Zhaotai Therapies to develop ground-breaking CAR T-cell therapy in New Zealand

CAR T-cell therapy involves redirecting a patient’s own immune system to impart long-lasting protection against cancer. By re-programming immune cells, we can fight cancer in more precise and targeted ways in situations where existing treatments such as surgery, chemotherapy and radiation are no longer an option.